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2025 Week Sixteen Picks
| Favorite | Line | Underdog | Trips Pick | Result |
 | 1.5 |  | | Bills 35 Patriots 31 |
 | 2.5 |  | | Commanders 29 Giants 21 |
 | 1.5 |  | | Broncos 34 Packers 26 |
 | 2.5 |  | | Saints 20 Panthers 17 |