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2025 Week Eighteen Picks
| Favorite | Line | Underdog | Trips Pick | Result |
 | 1.5 |  | | Texans 20 Chargers 16 |
 | 2.5 |  | | Saints 34 Titans 26 |
 | 2.5 |  | | Giants 34 Raiders 10 |
 | 1.5 |  | | Eagles 13 Bills 12 |