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2025 Week Two Picks
| Favorite | Line | Underdog | Trips Pick | Result |
 | 3.5 |  | | Iowa State 16 Iowa 13 |
 | 2.5 |  | | Illinois 45 Duke 19 |
 | 5.5 |  | | Missouri 42 Kansas 31 |
 | 3.5 |  | | Ohio 17 WVU 10 |
 | 4.5 |  | | Oklahoma 24 Michigan 13 |
 | 8.5 |  | | Eagles 24 Cowboys 20 |
 | 4.5 |  | | Jaguars 26 Panthers 10 |
 | 1.5 |  | | Buccaneers 23 Falcons 20 |
 | 1.5 |  | | 49ers 17 Seahawks 13 |