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2025 Week Five Picks
| Favorite | Line | Underdog | Trips Pick | Result |
 | 4.5 |  | | Notre Dame 56 Arkansas 13 |
 | 3.5 |  | | Louisville 34 Pitt 27 |
 | 4 |  | | Duke 38 Syracuse 3 |
 | 1.5 |  | | Ole Miss 24 LSU 19 |
 | 3.5 |  | | Oregon 30 Penn State 24 (2 OT) |
 | 5.5 |  | | Patriots 42 Panthers 13 |
 | 3.5 |  | | Rams 27 Colts 20 |
 | 2.5 |  | | Chiefs 37 Ravens 20 |
 | 2.5 |  | | Dolphins 27 Jets 21 |